By J. W. Hadden (Eds.)
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Extra info for Advances in Immunopharmacology. Proceeding of the Fourth International Conference on Immunopharmacology, Osaka, Japan, 16–19 May 1988
Leucocytosis, lymphocytosis and eosinophilia in peripheral blood were noted in all treated groups. Abnormal hepatic functions (increase of GOT, GPT, alkaline 32 Y . H a r a d a e t al Photo. 1. 4m Liver of a rat received 25 yg/kg/day of r-IL-2 for 13 weeks shows pseudolobules in parenchyma with fibrosis and disruption of normal architecture. Photo. 2. 4^ Subcutis of the same rat reveals marked fibrosis extended to deep layer. phosphatase and bilirubin levels) were found in association with slight anemia and thrombocytopenia in peripheral blood, eosinophilia in bone marrow as well as decreased αϊ-, a2-globuIin and increased γ-globulin in the 50 and 500 yg/kg/day groups.
A l t e r n a t i v e l y , l y m p h o c y t e s m i g h t have fewer CRF r e c e p t o r s w h i c h i n an i n s i t u b i n d i n g a s s a y may a p p e a r a s b a c k g r o u n d b i n d i n g . U s e o f an a n t i s e r u m t o tHe ACTH r e c e p t o r ( B o s t , e t a l . , 1 9 8 5 ) h a s d e m o n s t r a t e d a d i f f e r e n t i a l d i s t r i b u t i o n o f c e l l s b e a r i n g t h e s e r e c e p t o r s w i t h i n l y m p h o i d o r g a n s a n d among c e l l t y p e s , i n c l u d i n g Β c e l l s , Τ c e l l s , and macrophages ( J o h n s o n , et a l .
Carlson, D . L. Bellinger and D . L. Feiten (1985). Involvement of peripheral and central Overview on Neuroimmunomodulation 45 catecholamine systems in neural-immune interactions. J. Neuroi m m u n o l . , 1 0 , 5-30. , 0 . Kadlecová and P. Petrovicky (1985). The involvement of brain structures in the adjuvant effect of muramyl dipeptide. , 15. 4 4 3 - 4 6 6 . Masek, K. and 0 . Kadlecová (1987). Muramyl peptides, serotonergic system and sleep. Ann. N. Y . Acad. , 496, 5 1 7 - 5 2 1 . Weigent, D .
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